What if the bench top system used in the research lab that is the basis of core process knowledge had a DCS with all of the major control technologies embedded? What if a dynamic model was embedded in the DCS to form a virtual plant that enabled exploring, discovering, and prototyping optimum operating conditions and advanced controls? What if a process trial run that normally takes 10 days could be completed in 10 minutes? What if the benefits demonstrated could help develop and justify better online analytical measurements, advanced controls, and data analytics? What if the model and control system could be scaled up to the pilot plant and ultimately the commercial plant? What if the same model and control system could be deployed to the industrial facility and be used for operator training and the development of process diagnostics?
A pioneer out west is making this future a reality. Scott Broadley, the president of Broadley-James, asked himself what if the pH and dissolved oxygen electrodes he was selling were packaged with a bench top bioreactor and a DCS optimized to make it more flexible and easier to use by the biochemist in the lab environment. He had the vision and conviction to put a DeltaV DCS with all of its innate capability on bench top bioreactors when others were going for the cheapest lab controller they could find. With determination and insight, Scott grew the business into a state of the art operation. But this was just the beginning. After seeing my demo of a virtual plant at Interphex 2007 in the Emerson booth next door, Scott thought what if a virtual bioreactor could be part of a concept to accelerate process development through dynamic modeling and advanced control embedded in the DCS. Even though it was a major expense and a 2 year commitment to run dozens of 10 to 20 day bioreactor batches, he saw the potential. In the process of the beta test, he found new probes that could measure media components, amino acids, and cell volume, size, and viability online. Even the possibility of measuring product and precursors to cell death online now appears to be within reach opening the door to incredible opportunities to increase product concentration and quality through media and amino acid concentration and batch profile control. Scott is convinced that the results will determine how bioreactors will be run for the next 15 years.
The beta test team of Trish Benton, Broadley-James cell consultant, and Michael Boudreau, Emerson principal consultant, has the right combination of skills and attitude to make it happen. The mammalian model prototype I developed in the fall of 2007 is moving forward in their fully capable hands. Michael scaled down my industrial size bioreactor (15,000 Liters) model to the lab scale (5 Liters) and incorporated the Broadley-James lab optimized control system to form a versatile virtual plant. The team is now in the throes of identifying the process conditions and parameters for an innovative new cell line and a scale up to 100 Liter Single Use Bioreactors (SUB). For more information on the beta test, check out the article "PAT Tools for Accelerated Process Development and Improvement" at http://www.easydeltav.com/news/viewpoint/BioProcess0308.pdf
None of this would have happened without the understanding, support, and encouragement provided by Grant Wilson, vice president of DeltaV Technology, who has the PAT and technical background to see the opportunity. Ever since my first PAT presentation with Grant on bioreactor modeling and control at the 2005 Emerson Exchange, Grant has been the best advocate for advancing PAT through modeling and control.
Is there such a thing as free record databases? ...short of going to the courthouse.
Of all furniture, benches are the only firiture that can be ordered online, as they are pretty small, and at the same time can be packaged to a size that postal service can handle.
Hey I was just strolling through the web, looking for some interesting sites to link to and found yours. Some nice stuff on here and a load of great info. Should you have a moment, drop by and have a look at my work and give me a comment.
It is funny how many different sites there are on this topic I don't know if I'm ever going to have to come back, but it is great to know I stumbled upon the one that offers a little useful stuff if this ever comes up for me another time.
Couldn't be more impressed with this website and the great content. Please keep up the good work. Good, informative sites are getting harder and harder to find.
Good day! I am new in this particular Community forum and i wish just that anybody possibly can advise for me. I necessitate the perfect software program that alter pics and simply portraits. Potentially Photoshop is a super possibility, sadly i must say i do not find out if this particular tool can be much too unmanageable for the purpose of me personally. Easily because i have ın no way previously worked by using a good software like that Adobe Photoshop pc program. Posses somebody an theory which sorts for programme might be really good relating to any kind of starter?
Great Review and fascinating. Appreciate you taking the time in sharing these particulars. Thanks.
I've been into blogging for quite some time and this is definitely a effective and well written post. I signed up for your newsletter and shared it with my other blogger friends, so please keep up the informative posts!
Good luck on your blog, and feel free to comment and subscribe to my blog as well when you get a chance: Make Money Online with Dino Vedo.
Thanks so much, and lets stay connected and maybe share some ideas, do some guest posts, and get us both some more traffic and backlinks!
All the best,
Dino Vedo
Georgia Widick
Keep working ,great job!
Every body understands that our life seems to be not cheap, but we require money for various stuff and not every person gets big sums cash. Therefore to receive some credit loans or just bank loan will be a proper solution.
I would like to thank you for the efforts you have made in writing this article. I am hoping the same best work from you in the future as well. In fact your creative writing abilities has inspired me to start my own BlogEngine blog now. Really the blogging is spreading its wings rapidly. Your write up is a fine example of it.
Thanks for this! I’ve been searching all over the web for the facts.
Wow! This really is 1 of the most beneficial blogs We have ever are available across on this subject. Merely Magnificent
The Best Premium Tobacco Electronic Cigarettes - Try it yourself !
This information I Found on Yahoo From your Blog For me is Very useful and Helpful thanks For the Nice Read Looking Forward To Reading Some More From you
Maintain up the excellent function mate. This weblog submit indicates how nicely you realize and know this subject.
Wow! That is 1 of the top blogs We have ever arrive across on this subject. Basically Amazing
Very special Stuff! When i had been simply imagining that there are such a lot of amiss insight within the idea but you absolutely replaced our viewpoint. Looking through an excellent submit.
I truly like your post. I discovered it very usefull. I must go to your internet site again some day.
I am really liking this website accept I have a problem with making the RSS feed to work on the new Google Chrome. Any help? Thanks a million!